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Lets all talk about Bisphenol-A (BPA) before its too late 5-29-2024
Ask KEVIN aka "Karen" (XF444) why HE wont talk about Bisphenol-A (BPA) 5-29-2024 #2
Abstract
Bisphenol A (BPA) is an estrogenic endocrine disruptor widely used in the production of plastics. Increasing evidence indicates that in utero BPA exposure affects sexual differentiation and behavior; however, the mechanisms underlying these effects are unknown. We hypothesized that BPA may disrupt epigenetic programming of gene expression in the brain. Here, we provide evidence that maternal exposure during pregnancy to environmentally relevant doses of BPA (2, 20, and 200 µg/kg/d) in mice induces sex-specific, dose-dependent (linear and curvilinear), and brain region-specific changes in expression of genes encoding estrogen receptors (ERs; ERa and ERß) and estrogen-related receptor-? in juvenile offspring. Concomitantly, BPA altered mRNA levels of epigenetic regulators DNA methyltransferase (DNMT) 1 and DNMT3A in the juvenile cortex and hypothalamus, paralleling changes in estrogen-related receptors. Importantly, changes in ERa and DNMT expression in the cortex (males) and hypothalamus (females) were associated with DNA methylation changes in the ERa gene. BPA exposure induced persistent, largely sex-specific effects on social and anxiety-like behavior, leading to disruption of sexually dimorphic behaviors. Although postnatal maternal care was altered in mothers treated with BPA during pregnancy, the effects of in utero BPA were not found to be mediated by maternal care. However, our data suggest that increased maternal care may partially attenuate the effects of in utero BPA on DNA methylation. Overall, we demonstrate that low-dose prenatal BPA exposure induces lasting epigenetic disruption in the brain that possibly underlie enduring effects of BPA on brain function and behavior, especially regarding sexually dimorphic phenotypes.
Ask KEVIN aka "Karen" (XF444) why HE wont talk about Bisphenol-A (BPA) 5-29-2024
Abstract
Bisphenol A (BPA) is an estrogenic endocrine disruptor widely used in the production of plastics. Increasing evidence indicates that in utero BPA exposure affects sexual differentiation and behavior; however, the mechanisms underlying these effects are unknown. We hypothesized that BPA may disrupt epigenetic programming of gene expression in the brain. Here, we provide evidence that maternal exposure during pregnancy to environmentally relevant doses of BPA (2, 20, and 200 µg/kg/d) in mice induces sex-specific, dose-dependent (linear and curvilinear), and brain region-specific changes in expression of genes encoding estrogen receptors (ERs; ERa and ERß) and estrogen-related receptor-? in juvenile offspring. Concomitantly, BPA altered mRNA levels of epigenetic regulators DNA methyltransferase (DNMT) 1 and DNMT3A in the juvenile cortex and hypothalamus, paralleling changes in estrogen-related receptors. Importantly, changes in ERa and DNMT expression in the cortex (males) and hypothalamus (females) were associated with DNA methylation changes in the ERa gene. BPA exposure induced persistent, largely sex-specific effects on social and anxiety-like behavior, leading to disruption of sexually dimorphic behaviors. Although postnatal maternal care was altered in mothers treated with BPA during pregnancy, the effects of in utero BPA were not found to be mediated by maternal care. However, our data suggest that increased maternal care may partially attenuate the effects of in utero BPA on DNA methylation. Overall, we demonstrate that low-dose prenatal BPA exposure induces lasting epigenetic disruption in the brain that possibly underlie enduring effects of BPA on brain function and behavior, especially regarding sexually dimorphic phenotypes.
KY Pedo, LLC thief & liar & MAN who had his dick & balls cut off give EZ "advice" 5-29-2024 #2
Ask Nikalina about the thousands she stole from her employer "Below Closeout LLC"
Ask Nikalina why she called me a "Pedo" when she knows its a lie
Ask Nikalina why Josh had to sell his Mustang and go into hiding
Ask Kevin why he chopped his "floppy" off and thinks hes a woman
Its time to take out the trash
KY Pedo, LLC thief & liar & MAN who had his dick & balls cut off give EZ "advice"
Ask Nikalina about the thousands she stole from her employer "Below Closeout LLC"
Ask Nikalina why she called me a "Pedo" when she knows its a lie
Ask Nikalina why Josh had to sell his Mustang and go into hiding
Ask Kevin why he chopped his "floppy" off and thinks hes a woman
Its time to take out the trash
The Real Deal on "Aliens" 5-28-2024
AB- John Lear- September 2, 1994 radio interview
https://www.youtube.com/watch?v=q-LXWuaAcZc
News 5-28-2024
Left of Left Kali-Fornia Katie thinks shes a "conservative Republican"! 5-28-2024 #2
Left of Left Kali-Fornia Katie thinks shes a "conservative Republican"! 5-28-2024
Well Well Well... What do we have here!!! 5-28-2024
Tarot Anyone? @MMOTAROT 5-28-2024
Lets start the week with a BANG!: Is Trump the "Anti-Christ"? 5-28-2024 #2
Lets start the week with a BANG!: Is Trump the "Anti-Christ"? 5-28-2024
My gift for David Shurter and other Targeted Individuals 5-28-2024
Search Faraday Cage
My gift for David Shurter and other Targeted Individuals 5-28-2024
Search Faraday Cage
David Shurter knows Jay Parker 5-28-2024
Nephilina Family History 5-27-2024
"News" from the Pedophile channel 5-27-2024
Lawyer Talk with Lindsey Fry aka Nikalina & Meh Noodles 5-27-2024 #4
Still waiting for any proof at all that Alan Krebs aka ME is a Pedophile Nik!
You are a LIAR and a Thief and will go to JAIL.
Lawyer Talk with Lindsey Fry aka Nikalina & Meh Noodles 5-27-2024
Still waiting for any proof at all that Alan Krebs aka ME is a Pedophile Nik!
You are a LIAR and a Thief and will go to JAIL.
Lawyer Talk with Lindsey Fry aka Nikalina & Meh Noodles 5-27-2024
Still waiting for any proof at all that Alan Krebs aka ME is a Pedophile Nik!
You are a LIAR and a Thief and will go to JAIL.
Lawyer Talk with Lindsey Fry aka Nikalina & Meh Noodles 5-27-2024
Still waiting for any proof at all that Alan Krebs aka ME is a Pedophile Nik!
You are a LIAR and a Thief and will go to JAIL.
Casting Out STUBBORN DEMONS - Cleanse Your Temple 5-27-2024 #2
https://youtu.be/11ENb1XKFSE?t=5221
Casting Out STUBBORN DEMONS - Cleanse Your Temple 5-27-2024
https://youtu.be/11ENb1XKFSE?t=5221
The Jerry Springer of YouTube 5-27-2024
"Interesting" news and rumors of the day.