Glutathione is the body’s master antioxidant, synthesized endogenously from the 3 amino acids cysteine, glutamic acid, and glycine. NAC works to increase GSH levels during times of acute depletion, however it may not be ideal to increase glutathione levels beyond homeostasis. In this video we review 4 nutrients that cumulatively have a dramatic effect GSH on production in the body, plus what I consider to be two of the best research-verified supplements to increase cell GSH levels in the long run; whey protein and Glyteine / Continual G.
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Source Links:
1) Glutathione! [Joseph Pizzorno, ND, Editor in Chief] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684116/
2) Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency: https://pubmed.ncbi.nlm.nih.gov/12499341/
3) Vitamin C elevates red blood cell glutathione in healthy adults
https://pubmed.ncbi.nlm.nih.gov/8317379/
4) Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children: https://pubmed.ncbi.nlm.nih.gov/10977039/
5) Role of selenium and glutathione peroxidase on development, growth, and oxidative balance in rat offspring: https://pubmed.ncbi.nlm.nih.gov/24080144/
6) Selenium regulation of glutathione peroxidase in human hepatoma cell line Hep3B: https://pubmed.ncbi.nlm.nih.gov/8391784/
7) α-Lipoic acid protects against the oxidative stress and cytotoxicity induced by cadmium in HepG2 cells through regenerating glutathione regulated by glutamate-cysteine ligase:
https://pubmed.ncbi.nlm.nih.gov/26365678/
8) Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein: https://pubmed.ncbi.nlm.nih.gov/15463873/
9) Immuno-enhancing property of dietary whey protein in mice: role of glutathione: https://pubmed.ncbi.nlm.nih.gov/2743633/
10) The biological activity of undenatured dietary whey proteins: role of glutathione: https://pubmed.ncbi.nlm.nih.gov/1782728/
11) A Cysteine-Rich Whey Supplement (Immunocal®) Provides Neuroprotection from Diverse Oxidative Stress-Inducing Agents In Vitro by Preserving Cellular Glutathione:
https://pubmed.ncbi.nlm.nih.gov/28894506/
12) Effect of supplementation with a cysteine donor on muscular performance: https://pubmed.ncbi.nlm.nih.gov/10517767/
13) γ-Glutamylcysteine ameliorates oxidative injury in neurons and astrocytes in vitro and increases brain glutathione in vivo: https://www.sciencedirect.com/science/article/abs/pii/S0161813X10002299
14) Oral administration of γ-glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomized human trial pilot study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5284489/
15) Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855430/
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