More than a year on from the first UK lockdown, COVID-19 has had an undeniable impact on our daily lives.

Disruption to our routines, uncertainty about work and money, general health issues and dealing with unexpected caring responsibilities continue to affect how we’re feeling and coping.

We asked you how you were feeling, and analysed your responses in the ZOE COVID Study app to determine how COVID affected our mental health. In this webinar, we'll look at what effects the pandemic threat, and contracting the virus itself, had on our mental and physical health.

Featuring:
Prof. Tim Spector, OBE
Lead investigator on the ZOE COVID Symptom Study app

Prof. Tim Spector is a scientific co-founder at ZOE, lead scientist of the ZOE COVID Symptom Study, professor of genetic epidemiology and director of the TwinsUK Registry at King's College, London. Having published over 800 research articles, he is ranked in the top 1% of the world's most-cited scientists by Thomson-Reuters. He is also a prolific writer, with several popular science books including 'The Diet Myth' and 'Spoon-Fed'.

Dr. Claire Steves
Principal Investigator of the ZOE mental health survey, King's College London

Claire is a Reader at King’s College London. She is also a Consultant Geriatrician at Guys and St Thomas’s NHS Foundation Trust as well as the Deputy Director (Clinical) for TwinsUK. Claire is interested in the interactions between physical and mental health in ageing.

Brendan Street
Professional Head of Emotional Wellbeing at Nuffield Health

Brendan is a BABCP Accredited Cognitive Behavioural Psychotherapist and Supervisor, fully qualified EMDR (Eye Movement Desensitisation and Reprocessing) practitioner, and NMC registered Mental Health Nurse. Brendan has over 25 years-experience of treating mental health problems in the NHS and private sector.

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Our poo can tell us a lot about our health.

By taking part in The Big Poo Review, in conjunction with Channel 4's Steph's Packed Lunch, and telling us about your poo, you'll be contributing to the UK's largest nationwide survey conducting scientific research on our bowel habits. Together, we'll be able to help the nation understand what normal looks like and provide advice about what might be cause for concern.

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Today marks 3 years since the launch of the ZOE Health Study - formerly known as the COVID Symptom Study. Over that time, our incredible community of contributors have submitted over 568 million reports, logged over 32 million COVID test results and helped us identify over 20 symptoms of COVID, amongst other huge milestones that we're still reaching now with the Big Poo Review and the Big IF Study!

Thank you so much to everyone that's been there from the start, and those of you who are newly joined community scientists. We couldn’t do this without you!

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Today, we’re talking about the century-old paradigm of weight management — calorie counting. Rooted in the law of thermodynamics, the notion is simple: consuming fewer calories than expended results in weight loss.

While seemingly straightforward, the practical application of calorie counting can prove challenging, with many of us underestimating our calorie intake or finding it difficult to maintain this diet long-term.

In this special episode of ZOE Science & Nutrition, Jonathan is joined by Christopher Gardner, Professor of Medicine at Stanford University and the Director of Nutrition Studies at Stanford Prevention Research Center. Together, they explore this diet's complexities, addressing its potential and pitfalls.

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In the second results update from the Big Poo Review, ZOE US Medical Director and Gastroenterologist Dr Will Bulsiewicz brings you more fascinating insights from the Big Poo Review survey, launched together with Channel 4's Steph's Packed Lunch.

He'll share who and where is spending the most time on the loo, as well as what we've discovered about how many of you are suffering from constipation and diarrhoea in the UK. He'll also chat through some practical tips on what you can do to help solve these issues and help to keep your bowel habits healthy and regular.

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Heart disease is among the top five causes of death globally. So what simple steps can you take take, even in your later years, to reduce your risk?

Jonathan talks with Prof. Eric Rimm to try and find out.

Eric Rimm is an Associate Professor of Epidemiology and Nutrition and Director of the Program in Cardiovascular Epidemiology at the Harvard T.H. Chan School of Public Health.

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You may have heard there are bugs in your gut. But do they matter?

Today, the evidence shows the answer is a resounding yes. This ecosystem of tiny microbes living in our bodies is one of the most exciting areas in medical research, linked to everything from metabolic to mental health.

So while many of us have heard that gut health is essential, few of us understand why and what we should do to support our gut bacteria.

In this episode, Jonathan speaks with Will Bulsiewicz to find out when our microbiome begins to form, the most effective ways to support our gut health, and the role these gut bacteria play in controlling our weight.

Will Bulsiewicz is a board-certified gastroenterologist, and New York Times bestselling author of the microbiome book Fiber Fueled.

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The menopause transition can bring unexpected challenges — the effects can significantly impact daily life and long-term health.

Dr. Mary Claire Haver is a board-certified gynaecologist and a menopause specialist. She's helped thousands of women in perimenopause and menopause to realise their health goals. In today’s episode, she joins Jonathan and ZOE's Chief Scientist Dr. Sarah Berry to shed light on what to expect during these life stages.

Sarah and Mary Claire describe practical strategies for managing symptoms, critical conversations to have with healthcare providers, and how to advocate for yourself effectively in medical settings.

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What should I have for dinner? A question you no doubt ask yourself daily. But I bet you don't spend too long coming up with an answer. ZOE's scientific co-founder, Tim Spector, has been trying to answer this question for a decade.

If you're a regular listener, you probably know him well. Five years ago, he published the best-selling book, The Diet Myth, and just last month, he released the follow-up, Food for Life, the New Science of Eating Well.

In this episode, you'll hear a chapter from the book titled “So Now What Should I Have for Dinner?”

Tim Spector is a co-founder of ZOE and one of the world's top 100 most-cited scientists

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What are the foods you should avoid to combat gas and bloating?

Jonathan is joined by Dr. Will Bulsiewicz to explore the topic.

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It’s no wonder that a huge selection of supplements claim to relieve menopause’s unpleasant effects.

More than half of women who go through menopause find its symptoms distressing. In fact, 10% leave their jobs because of the burden.

But do menopause supplements actually work? Which products are backed by clinical evidence, and which are just “menowashing”?

In today’s short episode of ZOE Science & Nutrition, Jonathan and Dr. Sarah Berry ask: What’s the evidence behind menopause supplements?

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The word ‘processed’ has become synonymous with being unhealthy. The mainstream media encourages us to detox from processed food or offers us ‘10 easy ways’ to stop eating it.

But nearly everything we consume has undergone some type of processing.

In today’s short episode of ZOE Science and Nutrition, Jonathan and Sarah ask: If most of what we eat is processed, can it really be that unhealthy for us?

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What’s the cheapest way to get enough protein?

Jonathan speaks with Dr. Rupy Aujla and Tim Spector to try and find out.

Dr. Rupy Aujla is a medical doctor who, since 2015, has been teaching people to cook their way to health as the founder of the doctor’s kitchen and has recently turned his efforts to doing so on a tight budget.

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Developing healthier eating habits could give you many more healthy years. What’s the formula for creating habits that stick?

Jonathan talks with James Clear to find out.

James Clear is a writer, speaker, and author of the New York Times bestseller Atomic Habits.

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If you're confused about the health effects of fats, you are not alone. You've probably read the headlines - fats are killing us! Then found claims they’re actually healthy in the same publication the following week.

Saturated fats have been touted as the worst of all.

While there’s ambiguity around other fat sources, saturated fats are universally demonized.

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In the third instalment of COVID Question Time, Professor Tim Spector answers more of your top questions sent in via the ZOE COVID Study app.

In this week's video:

00:00 - Intro

00:22 - What is the current sensitivity for lateral flow tests and are they as effective at detecting other variants such as the Indian variant? Anonymous

04:40 - My sons aged 20 & 21 received a first dose of AstraZeneca in March. Is there any way they could have a different 2nd vaccine as we are now worried about risk of clots? Beth & Boosters may be offered by the end of the year . Will it matter if we are given a different one from our vaccine? Anonymous

08:43 - Public Health England say AstraZeneca is 60% effective against infection by the Indian variant. Great but still leaves quite a risk? And is it 60% for all or less if obese/high risk? Caroline

11:55 - Can you show the current infection levels across the age bands and compare this with vaccine uptake percentages, to show if the link between has been broken. Anonymous

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Each day this week, we’re examining one of the world’s most popular diets. Putting the latest scientific evidence under the microscope, we’ll find out these diets' true impact on your health.

Today we’re talking about the carnivore diet, a zero-carb regimen centered on meat, fish, eggs, and minimal dairy, while excluding all plant foods and alcohol.

Advocates claim benefits in autoimmune conditions, type 2 diabetes, and weight loss, asserting that our ancestors thrived on this diet. However, this controversial diet does raise questions about nutrient deficiencies and excessive saturated fat intake.

In this special episode of ZOE Science & Nutrition, Jonathan is joined by Christopher Gardner, Professor of Medicine at Stanford University and the Director of Nutrition Studies at Stanford Prevention Research Center. Together, they explore its purported advantages and drawbacks.

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Which COVID-19 vaccine should you take? Will you have the option to choose? And what's the difference between the Oxford AstraZeneca vaccine vs. the Pfizer vaccine? Which COVID-19 vaccine is more effective?

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ZOE's technology uses the most advanced scientific lab tests to help you better understand your microbiome, blood sugar response and blood fat response. Once you've tested your body, our technology will give you a bespoke eating plan based on your metabolic health.

ZOE is based on years of independent science and research with scientists and researchers at Stanford, Harvard, Massachusetts General Hospital, King's College London and my more. The program uses cutting edge technology and AI to compare your metabolic profile to thousands of others, helping you to understand what makes your body different.

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As we age, it's seen as normal for our mental and physical health faculties to worsen as the years go by. But Dr Peter Attia thinks that is NOT the case.

Jonathan and Peter explore healthspan vs lifespan so you can find out how to stay young as you age.

Dr Peter Attia is a medical doctor and founder of the Early Medical Practice, a private clinic in America, which helps patients lengthen their lifespan while simultaneously improving their ‘healthspan’. He is also the author of the New York Times bestseller: Outlive: The Science and Art of Longevity

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This week, Professor Emma Duncan from King's College London answers your questions on COVID vaccines and menstruation, and whether or not they can affect your cycle.

Please note, Emma advises that if you’re experiencing irregular bleeding or disruption to your periods for more than one or two cycles, you should talk about this with your GP. She also adds that anyone who has had a period (or bleed, of any duration) after 12 months without menstruation should see their GP, irrespective of whether this is a ‘one-off’ or a continuing problem.

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Tim looks back at all of the brilliant achievements from the ZOE Health Study over the last year, 2022. He reviews the major studies we ran in the app, including the blood pressure study, the Big Diet study and the Big IF Study and the key results we discovered.

He also looks at COVID rates across the year, how they've changed, and how the rates of non-COVID respiratory illnesses are currently well in the lead in terms of cases. Tim also gives a sneak peak into what to expect in 2023, and which exciting studies we have coming up in the ZOE Health Study.

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Menopause affects half of us, but there are still many unanswered questions. In today’s short episode, Jonathan and Sarah ask: What role does your diet play?

It's a condition that affects half the population, but there are countless unanswered questions about menopause. The symptoms vary significantly from person to person, including sleep problems, hot flashes, weight gain, and an increased risk of heart disease.

In one of the largest studies to date, ZOE researchers have uncovered a link between menopause and our diets — and this could hold the key to reducing the severity of menopause symptoms

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Tim looks at a brand new COVID treatment called Molnupiravir. This is a pill with a real potential to help reduce deaths and hospitalisations in patients with COVID, with initial results from the trial looking very promising. He discusses the mechanism behind how it works, as well as what the limitations are for a treatment like this.

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Our first paper on vaccines is published today in The Lancet Infectious Diseases!
Professor Tim Spector discusses the latest findings in the brilliant data from our ZOE app users, which has helped us give a positive insight into vaccine effectiveness and safety. Huge congratulations to the science teams at ZOE and King's College London

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